DB01113 Papaverine


  1. Phosphodiesterase Inhibitors
  2. Vasodilator Agents


  1. Approved
  2. Small Molecule


  1. Liquid Intravenous


  1. An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. [PubChem?]


  1. Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries.


  1. Not Available


  1. Alapav
  2. Artegodan
  3. Cardiospan
  4. Cardoverina
  5. Cepaverin
  6. Cerebid
  7. Cerespan
  8. Delapav
  9. Dilaves
  10. Dispamil
  11. Drapavel
  12. Durapav
  13. Dynovas
  14. Forpavin
  15. Genabid
  16. Myobid
  17. Optenyl
  18. Pameion
  19. Pamelon
  20. Panergon
  21. Pap H
  22. Papacon
  23. Papalease
  24. Papanerin
  25. Papanerin-Hcl
  26. Papanerine
  27. Papaversan
  28. Papital T.R.
  29. Paptial T.R.
  30. Pavabid
  31. Pavabid Hp
  32. Pavacap
  33. Pavacels
  34. Pavacen
  35. Pavacot
  36. Pavadel
  37. Pavagen
  38. Pavakey
  39. Pavarine
  40. Pavased
  41. Pavatest
  42. Pavatine
  43. Pavatym
  44. Paverolan
  45. Paveron
  46. Pavnell
  47. Qua Bid
  48. Ro-Papav
  49. Robaxapap
  50. Spasmo-Nit
  51. Therapav
  52. Vasal
  53. Vaso-Pav


  1. Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.


  1. Solid


  1. For the treatment of impotence


  1. Chlorhydrate de Papaverine
  2. Papavarine Chlorhydrate
  3. Papaverin
  4. Papaverine Chlorohydrate
  5. Papaverine Hcl
  6. Papaverine Hydrochloride
  7. Papaverine Monohydrochloride
  8. Papaverinium Chloride


  1. 15457029 Tang Y, Luan J, Zhang X: Accelerating tissue expansion by application of topical papaverine cream. Plast Reconstr Surg. 2004 Oct;114(5):1166-9.
  2. 15519189 Takeuchi K, Sakamoto S, Nagayoshi Y, Nishizawa H, Matsubara J: Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting. Eur J Cardiothorac Surg. 2004 Nov;26(5):956-9.
  3. 16159054 Liu JK, Couldwell WT: Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2005;2(2):124-32.


  1. Not Available


  1. Not Available


  1. A03AD01
  2. G04BE02


  1. Not Available